1), protect genome from degradation and interchromosomal fusion. ![]() Telomeres, the DNA–protein complexes at chromosome ends ( Fig. In this review we highlight the lifestyle factors that may adversely affect health and lifespan of an individual by accelerating telomere shortening and also those that can potentially protect telomeres and health of an individual. Certain agents associated with specific lifestyles may expedite telomere shortening by inducing damage to DNA in general or more specifically at telomeres and may therefore affect health and lifespan of an individual. Telomere length may therefore serve as a biological clock to determine the lifespan of a cell and an organism. When telomere length reaches a critical limit, the cell undergoes senescence and/or apoptosis. As a normal cellular process, a small portion of telomeric DNA is lost with each cell division. ![]() Telomeres therefore play a vital role in preserving the information in our genome. ![]() Telomeres, the specific DNA–protein structures found at both ends of each chromosome, protect genome from nucleolytic degradation, unnecessary recombination, repair, and interchromosomal fusion.
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